A cholesterol-lowering vaccine has shown promise in mice, said researchers Tuesday who announced they had started early-phase trials to see if it also works in humans.
Such a treatment could offer a welcome alternative to statins, the main pharmaceutical choice today for lowering cholesterol in people at high risk of heart attack or stroke.
The vaccine, dubbed AT04A, reduced cholesterol levels in trial mice by half, and reversed damage done to blood vessels due to plaque buildup by more than 60 percent, researchers said in a statement.
The mice were given the vaccine after they were fed a fatty diet to resemble the high-cholesterol intake of a human Western-style diet.
“Levels of cholesterol were reduced in a consistent and long-lasting way,” said study co-author Guenther Staffler of the AFFiRis biotech company developing the treatment.
This, in turn, resulted in “a reduction of fatty deposits in the arteries and atherosclerotic damage, as well as reduced arterial wall inflammation.”
AT04A contains a molecule that causes the body to produce antibodies against an enzyme called PCSK9, which prevents the clearance of so-called “bad” cholesterol from the blood, according to a study published in the European Heart Journal.
The cholesterol-zapping antibodies persisted for months after vaccination, it said.
“If these findings translate successfully into humans, this could mean that… we could develop a long-lasting therapy that, after the first vaccination, just needs an annual booster,” said Staffler.